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Waterer T able 3.1 An tremendous size of genes ha v e been identif ied as ha ving potentialy important multiform sites Coagulation and tisue ameliorate Antigen acknowledgement Pro-inflammatory Anti-inflammatory pathw ays CD21040e (6tB ;a SaGl ik2eib0rn o0net2te e;ra tlNe a2ta l0a k2l0a 062d0;0a 20B e;5 atH; ra bTele e2rs0 ee0nt 5 a;l emple et al 2003) TNF (Barber et al 2006; Calv ano et al 2003; Gong et al 205; Gordon et al 204; Hedber g et al 204; Majetschak et al 1999; Mira et al 1999; Nakada et al 2005; Nuntayanuw at et al 1999; OТK eefe et al 2002; Stuber et al 1995; W aterer et al 2001; W estendorp et al 1997) IL-e1t0 a 2(l0B 20a03i0e;3 rG ;e oGt naagll 2ea0tg 0ha6le ;r2 B0et0a 6aldl; iLngo we et al 2003; Nakada et al 2005; Schaaf et al 2003; Shu et al 2003; Stanilo v a et al 200W6; soprano et al 2005; atanathum et al 2005; W estendorp et al 1997) Fibrinogen-beta (Manocha et al 2007) TL2R040e (2tB ;a 2aNl0 r2ba0ke50ra) 5d,e )aTt, aLeTltR L2a5R0l 02(2H60 (;0aS L5k;oi nSrenkneiznr neeett raa ll wn et al 2003) IL-1 . (W atanabe et al 205), IL-6 (Baier et al 2006; Balding et al 2003; composer et al 206; Schluter et al 202; soprano et al 205), IL-18 (Stasen et al 203) IL-(1A rreentca ealpli ct2oh0r e0 at3 na;t laF 2g0o0n2is;t Balding ang et al 1999) Protein-C (W alle y & vocaliser 2007) Lip(pBoaprobleyrs &acOhТaKride protection catalyst eefe 2003; Hubacek et al 2001) CXCL2 (Flores et al 2006) Heat jounce accelerator 70 comple x (Schroder et al 2003; W aterer et al 2003) V ascular endothelial gro wth f actor (Zhai et al 2007) IgG2 organ (also the C-reacti v e protein receptor) (Y uan et al 2003) L ymphotoxin alpha (Calv ano et al 2003; Majetschak et al 19; Rauchschw albe et al 2004; Stuber et al 1996; W aterer et al 2001) F actor V (W eiler etal 2004; Y an & admiral 2004) Myeloid dif fere(MntiDat-i2o)n ( pGruo teeti na-l2 2 007) Macrophage migration abstinence f actor (MIF) (Gao et al 2007) Apolipoprotein-E (Moreti et al 2005) C-reacti v e protein (Eklund et al 2006) Pre-B cellphone punctuation y rousing f actor (PBEF) (Bajw a et al 2007; Y e et al 2005) Plasminogen acti v ator inhibitor -1 (Bientd ae2lr0 2e0H0t5 0ea7rl; m b2G;0a eG0ni7se haieso;t h fBaoelirf n e1edr9t e 9eart9l a)2l05b; Ma2n0n0oa3ls ;e2 -G0b0oin6nd;g iK negrt o alnel bc2ot0irn0 7(G; Garorreddo g et al 2002; Ro y et al 2002) IRAK-1 (Arcaroli et al 2006) Surf actant-proteins (Gong Quasne y et al 2004) 3 The Genetics of Sepsis: The Promise, the Progress and the Pitfalls 33 As thither is substantive intersection between the functions of some cytokines, and frequently sextuple antagonists for some relinquished agonist, thither is a profound power to compensate for a predestinate sum of variation in yield of several cytokines. 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