This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase.
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Similarly, the systemic exposure after a dose of 56 mg/day in an induced population is expected to be comparable to the systemic exposure after a dose of 22 mg/day in a non-induced population.
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General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.
Other information may be gathered from past medical history including history of high blood pressure, high cholesterol, and diabetes.